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When to consider the diagnosis of EDS EhlersDanlos syndrome needs to be considered when, in the absence of another explanation, one or more of the following occur: late walking with joint hypermobility abnormal bruising and bleeding unexplained vessel rupture or dissection tissue fragility, atrophic scarring or skin hyperextensibility symptomatic joint hypermobility dislocations Hollow organ rupture A systematic approach to the patient with suspected EDS is essential to avoid costly and unnecessary investigations, but first one needs to be aware of the different subtypes within this group and their diagnostic features

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Chen J, Li H, Chen J

Example: Up to 70% of amoxicillin is excreted unchanged in urine during the first 6 hours after administration of one 500mg dose

Results revealed that the concentration of niclosamide in aqueous solution can be increased by simply increasing solution pH by only one to two logs, into the pH 8-9 range